The first people known to have entered the area of Alachua County were Paleo-Indians, who left artifacts in the Santa Fe River basin prior to 8000 BCE. Artifacts from the Archaic period (8000 - 2000 BCE) have been found at several sites in Alachua County. Permanent settlements appeared in what is now Alachua County around 100 CE, as people of the wide-ranging Deptford culture developed the local Cades Pond culture. The Cades Pond culture gave way to the Alachua culture around 600 CE.
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