Interstate 75 runs through North Fort Myers, with access from Exit 143 (Florida State Road 78). I-75 leads northwest 67 miles (108 km) to the Sarasota area and south 38 miles (61 km) to the Naples area, while SR-78 leads east 34 miles (55 km) to LaBelle and west 16 miles (26 km) to Pine Island Center. U. S. Route 41 (North Tamiami Trail) passes through the center of North Fort Myers, leading southeast across the Caloosahatchee Bridge into the center of Fort Myers and northwest 24 miles (39 km) to Port Charlotte.
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